000			02327nam a22003618i 4500
999			_c12263 _d12263
001			18577358
003			BD-DhDIU
005			20220908154759.0
008			150415s2016 nyu b 001 0 eng
010			_a 2015014810
020			_a9789814670241
035			_a(DNLM)101656208
040			_aDNLM/DLC _beng _erda _cBD-DhDIU
042			_apcc
050	0	0	_aRM301.4
060	1	0	_aQV 38
082	0	0	_a615.7 _223
100	1		_aShargel, Leon
245	1	0	_aApplied biopharmaceutics and pharmacokinetics / _cLeon Shargel and Andrew B.C. Yu.
250			_a7th ed.
260			_aNew York : _b McGraw-Hill Education _c2016
263			_a1511
300			_axvii, 910 p. : _c25 cm. _bill. ;
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis.
650	1	2	_aBiopharmaceutics. _9881
650	1	2	_aPharmacokinetics.
650	2	2	_aDrug Administration Routes.
650	2	2	_aModels, Chemical.
700	1		_aYu, Andrew B. C.
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2ddc _cBK _017